17^th Annual Congress on Pharmaceutics & Drug Delivery Systems September 20-22, 2018 Prague, Czech Republic | Panorama Hotel Prague | Milevská 7, 140 63 Praha

Sometimes called Medico-marketing or Pharma Marketing in some countries. It is the business of advertising or otherwise promoting the sale of pharmaceuticals or drugs. Emergences of new technology in recent years help in promotion. Pharmaceutical companies explore online marketing as an alternative way to reach physicians, their customers.

This market is expected to reach about $100.7 billion by 2019, registering a compound annual growth rate (CAGR) of 3.8% from 2014 to 2019

Regulatory affairs are a new profession which is developed by the governments to protect public health. The main aim is controlling the safety and efficacy of products in areas including pharmaceuticals, veterinary medicines, medical devices, pesticides, agrochemicals and cosmetics. Regulatory affairs also have a very specific meaning within the healthcare industries.

Vaccine is a product that produces immunity against a disease. Vaccines can prevent diseases and are very effective. Vaccine mobilizes the host immune system to prevent viral infection.it can break the chain of transmission. Vaccines provide active and passive immunity. Vaccines are made of the entire disease-causing microorganisms or some of its components. Smallpox vaccine is the first success vaccine. Immuno therapy is the treatment that uses certain parts of a person’s immune system to fight diseases such as cancer. 

An ideal drug delivery system needs to execute multiple tasks, which involves the highest degree of smartness. While delivering the drug at the desired location requires surface modification with a suitable targeting moiety that will enable the carrier to bind to cells of interest, delivery of necessary amount of drug necessitates incorporation of a trigger that will regulator the amount of drug released at a given instant.

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Delivery of therapeutic proteomics and genomics characterize a significant area of drug delivery research. Genomics and proteomics approaches could be used to direct drug development processes by unearthing pathways involved in disease pathogenesis where intervention may be most successful.

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These novel systems involve use of nanoparticles, superparamagnetic materials, protein biosensors, and advanced light assisted molecular immobilization technology. The group has acquired fundamental knowledge on light activated mechanisms in protein structures. Using ultraviolet‐light it is possible to open disulphide bonds in proteins leading to protein immobilization onto thiol reactive surfaces (glass, quartz or gold surfaces).

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Sustained drug delivery has the prospective to improve the treatment and prevention of many circumstances and diseases that afflict the female reproductive tract. However, achieving effective, therapeutic delivery in the vaginal tract is challenging due to vaginal physiology. To overcome these issues, we are emerging nanomedicines and novel delivery vehicles that can provide sustained release (improving effectiveness) and deliver drugs uniformly to the target surface.

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The importance of drug delivery to chemists, medicinal and otherwise, has increased since the advent of integrated drug discovery processes. Physicochemical and biological barriers, pathways for drug delivery, formulation, pharmacokinetic and pharmacodynamics issues, metabolism, and cell culture models used in studying drug delivery are just some of the topics that type drug delivery and stimulating field for researchers.

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Nuclear magnetic resonance (NMR) spectroscopy is the most widely applicable method for drug discovery and analysis. This technique provides a highly specific tool for identifying a drug substance containing impurities and residual solvents and their metabolites in biological media. It also provides a suitable analytical technique for their absolute quantification. In recent years, NMR spectroscopy has been increasingly used to monitor the cumulative drug release, drug dissolution, and diffusion coefficient of drugs from drug delivery systems in vitro and in vivo.

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Nanoparticles that are both synthetic HDL and contain a MRI different agent (iron oxide). The researchers are now conducting animal studies to determine how well the artificial HDL (high density lipoprotein) treats arterial plaque. Nanoparticle that can deliver drugs to tablet on the wall of an artery. They attach a protein called a peptide to a nanoparticle, which then binds with the surface of the plaque.

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The main objective in drug design is to foresee whether a given particle will bind to a target and if so how unequivocally. Molecular mechanics or molecular dynamics are regularly used to predict the conformation of the little particle and to model conformational changes in the biological targets that may happen when the little molecules ties to it. The remedial reaction of a drug relies on the cooperation of drug molecules with cell on cell membrane related biological events at receptor sites in concentration dependent manner.

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Pharmacodynamics is the significance that drugs have on the main part; while pharmacokinetics is the study of the way in which drugs move through the body during absorption, distribution, metabolism and excretion. Pharmacokinetics influences decisions over the route of administration. For drugs to produce their effects they must interact with the body. This can ensue in several behaviors and depends on the properties of the drug, and will be discussed later in this chapter. Pharmacokinetics influences decisions over the route of administration. The processes that occur after drug admin can be fragmented down into four distinct areas (known as ADME).

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Drug delivery describes the tactic and approach to delivering medicine or and different xenobiotics to their site of action inside an organism, with the goal of achieving a therapeutic outcome. problems with pharmacodynamics and pharmacokinetics area necessary concerns for drug delivery. Designing and developing novel drug delivery systems, with attention on their application to sickness conditions. diagnosis and clinical knowledge associated with drug delivery systems.

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Medical devices vary according to their intended use and indications. Examples range from simple devices such as tongue depressors, medical thermometers, and disposable gloves to advanced devices such as computers which assist in the conduct of medical testing, implants, and prostheses. The design of medical devices creates a major part of the field of mechanical engineering.

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Medicinal chemistry is a discipline at the overtone of chemistry, particularly synthetic organic chemistry, and pharmacology and various other biological specialties, where they are involved with design, chemical synthesis and development for market of pharmaceutical agents. Earlier, medicinal chemists often optimized and developed compounds without much knowledge of the drug target or pathway in mind. New skills have had an enormous impact on drug discovery since the mid-20th century.

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Pharmaceutical technology is the appliance of scientific knowledge or technology to pharmacy, pharmacology, and the pharmaceutical industry. It includes design, techniques, and instrumentation in the manufacture, preparation, compounding, dispensing, packaging, and accumulating of narcotic and other preparations used in diagnostic and determinative procedures and in the treatment of patients.

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Sustained Release Drug Delivery System (SRDDS) is designed to release a drug at a predetermined rate by maintaining a constant drug level for a specific period of time with minimum side effects. Now a day’s focus on the development of SRDDS has increased, as very few drugs are coming out of research and development and already existing drugs are suffering the problem of resistance due to their irrational use specifically in case of drugs like antibiotics. The major goal of designing SR formulations was intended to modify and improve the drug performance by increasing the duration of drug action, decrease the dosing frequency, reduced side effects, decreasing the required dose employed and providing the shortest possible time by using smallest quantity of drug administered by the most suitable route
 

There has been improved movement in the field in recent times concerning the development and research on various printing techniques in fabrication of dosage forms and drug delivery systems. A general overview of 2D printing techniques is presented including a review of the most recent literature where printing techniques are used in fabrication of drug delivery systems.The 3D printing has enabled the fabrication of prototypes of DDD with varying complexity and shows that customization of drug products is possible.

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Pharmaceutics is the investigation of connections between preformulation, pharmaceutical plan, conveyance, mien and clinical reaction. The intrinsic unsteadiness nature of another medication will modify its coveted frame into undesired shape when exhibited in a reasonable measurements frame with the excipient/s upon capacity. In early days this procedure was bound just to assess couple of attributes, however today this procedure is being considered as a detailing technique and henceforth gigantic mechanical headway has been accomplished in this field which empowers us to spare time and cash through arranged administration framework and subsequently impacts.

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Pharmaceutical and biotechnological research bonds protein drug delivery systems by reputation based on their various therapeutic applications. The effective and potent action of the proteins/peptides makes them the drugs of choice for the treatment of numerous diseases. Main investigation topics in protein delivery include the conservation of proteins in delivery devices and the design of appropriate target-specific protein carriers. Many efforts have been made for effective delivery of proteins/peptidal drugs through various routes of administrations for successful therapeutic effects.

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Nano medicine is the medical application of nanotechnology. Nano medicine shows from the useful applications of nanomaterials and biological devices, to Nano electronic biosensors, and even possible future applications of molecular nanotechnology such as biological machines. Current problems for Nano medicine involve understanding the issues related to toxicity and environmental impact of nanoscale materials. The industrialization of nanoscale titanium dioxide for a broad range of applications (most of which we are quite familiar with) is only one such example showing how nanomaterials have become a central component in the manufacturing process during the past decade.

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The Novel Drug delivery systems are the system by which a drug is delivered can have a important effect on its efficacy. Some drugs have an optimum concentration range within which maximum benefit is derived, and concentrations above or below this range can be toxic or produce no Local Drug Delivery Systems benefit at all. On the other indicator, the very slow development in the efficacy of the management of modest diseases, has suggested a growing need for a multidisciplinary approach to the delivery of therapeutics to targets in tissues. From this, new ideas on controlling the pharmacokinetics, pharmacodynamics.

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