Pranav Shah
Tarsadia University, India
Title: Formulation and evaluation of liquisolid compact based immediate release tablets of rivaroxaban
Biography
Biography: Pranav Shah
Abstract
Rivaroxaban is a potent selective oral direct factor Xa inhibitor, Rivaroxaban belongs to BCS Class II. Liquisolid system involves dissolving water insoluble drugs in non-volatile solvents and then converting them into dry, nonadherent, free- flowing and compressible powder mixtures by blending with selected carriers and coating materials. Liquisolid compacts (LSC) of poorly water soluble drug Rivaroxaban were prepared to enhance its dissolution rate and bioavailability. Liquisolid tablets were prepared using Polyethylene Glycol (PEG-400) as the non-volatile solvent with selected carriers and coating materials. The prepared liquisolid (LS) systems were evaluated for the flow properties.The physico–chemical properties of liquisolid systems were evaluated by Infrared spectra analysis (IR), Differential scanning calorimetry (DSC) and X- ray diffraction (XRD) and Scanning electron microscopy(SEM). DSC studies revealed that there was no interaction between the drug and carrier. XRD studies demonstrated that there was a loss in crystallinity of pure drug present in LS system. SEM indicating that the drug existed in a solid dosage form, it is held within the powder substrate in a solubilized, almost molecularly dispersed state, which contributed to the enhanced drug dissolution properties. And it is also complies with the results of XRD and DSC that the drug is in the liquisolid system. The liquisolid tablets were evaluated for Weight variation, Hardness, Drug content, Disintegration time and Dissolution rate. Liquisolid compact exhibited higher dissolution rate as compared to marketed tablet. This enhanced dissolution rate might be due to increased wetting properties and surface area of drug available for dissolution.