Hazal Ezgi Gültekin
Gazi University, Turkey
Title: Fused deposition modeling 3d printing technology: an effective tool for designing personalized dosage forms
Biography
Biography: Hazal Ezgi Gültekin
Abstract
3D printing (3DP) is a layer-by-layer production process which is used to manufacture 3D objects utilizing computer aided design data. In pharmaceutical area, fabrication of personalized dosage forms is one of the important advantages of this technology. Fused deposition modeling (FDM) is a widely used 3DP technology. In FDM, an extruded polymer filament passes through a heated nozzle and after moltening it deposits onto a build plate to create a hard object. Pramipexole is a commonly used drug for the symptomatic treatment of Parkinson’s disease.The aim of this study was to prepare pramipexole loaded 3DP tablets.
Firstly, drug loaded polymer filaments were prepared by hot melt extrusion (Filabot Filament Extruder). After that, by using these filaments 3DP tablets were printed via 3D printer (MakerBot® Replicator_ 2X Experimental 3D Printer). In the present study, scanning electron microscope (SEM) images of the filaments and the 3DP tablets were taken, the physico-pharmaceutical properties (weight uniformity, dimensions and friability) of the 3DP tablets were evaluated and in vitro dissolution profiles of commercial tablets and 3DP tablets were compared.
In conclusion, drug loaded 3DP tablets were successfully fabricated by FDM. This study demonstrates that fused deposition modeling 3D printing is an effective technology for the development of personalized dosage forms on the treatment of diseases.