Valery Bochkov
University of Graz, Austria
Title: Neutralization of inflammation induced by peroxidized phospholipids by non-antioxidant compounds
Biography
Biography: Valery Bochkov
Abstract
Oxidized phospholipids (OxPLs) represent an emerging class of lipid mediators generated by enzymatic or non-enzymatic oxidation of esterified polyunsaturated fatty acids. Multiple studies have characterized OxPLs as inducers of proinflammatory, procoagulant and proangiogenic mediators in a variety of cells and tissues. Accumulating evidence suggests that OxPLs induce these proteins through signaling pathways that are different from those utilized by the majority of physiological or pathological inducers of inflammation, blood clotting and angiogenesis. This presentation will discuss specific intracellular signaling mechanisms mediating induction of interleukin-8, tissue factor and VEGF by OxPLs. As a proof of principle for selective inhibition of OxPL-induced inflammation a new chemical scaffold will be described that selectively inhibits production of interleukin-8 by OxPLs but has minimal effects on the action of recognized inflammatory agonists such as cytokines (TNFa, IL-1b) or bacterial products (lipopolysaccharide). The study suggests new approaches for pharmacological protection against oxidative stress using non-antioxidant compounds.