Biomarkers Detection & Nanoparticle based Drug Delivery Systems
These novel systems involve use of nanoparticles, superparamagnetic materials, protein biosensors, and advanced light assisted molecular immobilization technology. The group has acquired fundamental knowledge on light activated mechanisms in protein structures. Using ultravioletâ€light it is possible to open disulphide bonds in proteins leading to protein immobilization onto thiol reactive surfaces (glass, quartz or gold surfaces). This work has paved the way for the development of a unique light assisted immobilization technology (LAMI) applied to the development of a new biosensor microarraying technology with micrometer and subâ€micrometer resolution and to engineering new nanoparticle based drug/protein carriers. The bioconjugates can be used to identify molecules that recognize and bind to the biomarker. The biomarker may indicate disease, and its corresponding receptor may provide knowledge for designing novel pharmaceuticals, which can be used for treatment.