Smart Drug Delivery Systems


An ideal drug delivery system needs to execute multiple tasks, which involves the highest degree of smartness. While delivering the drug at the desired location requires surface modification with a suitable targeting moiety that will enable the carrier to bind to cells of interest, delivery of necessary amount of drug necessitates incorporation of a trigger that will regulator the amount of drug released at a given instant. The trigger could either be a stimulus provided externally (extrinsic triggers) or could be due to the internal environment of the system in which the drug delivery system is introduced (internal triggers). In theoretical field, variety of smart DDSs have been plentifully demonstrated for various intriguing systems, such as stimuli-responsive polymeric nanoparticles, liposomes, metals/metal oxides, and exosomes.



 


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